41: Taddia L, D’Arca D, Ferrari S, Marraccini C, Severi L, Ponterini G, Assaraf YG, Marverti G, Costi MP. Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance. Drug Resist Updat. 2015 Nov;23:20-54. doi: 10.1016/j.drup.2015.10.003. Epub 2015 Oct 31. Review. PubMed PMID: 26690339.
42: Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015;22(37):4293-312. Review. PubMed PMID: 26477622.
43: Sacchetti F, Marraccini C, D’Arca D, Pelà M, Pinetti D, Maretti E, Hanuskova M, Iannuccelli V, Costi MP, Leo E. Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery. Colloids Surf B Biointerfaces. 2015 Dec 1;136:346-54. doi:10.1016/j.colsurfb.2015.09.040. Epub 2015 Sep 25. PubMed PMID: 26433347.
44: Eadsforth TC, Pinto A, Luciani R, Tamborini L, Cullia G, De Micheli C, Marinelli L, Cosconati S, Novellino E, Lo Presti L, Cordeiro da Silva A, Conti P, Hunter WN, Costi MP. Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity. J Med Chem. 2015 Oct 22;58(20):7938-48. doi: 10.1021/acs.jmedchem.5b00687. Epub 2015 Sep 16. PubMed PMID: 26322631; PubMed Central PMCID: PMC4621507.
45: Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. PubMed PMID: 25798950; PubMed Central PMCID: PMC4634673.
46: Santucci M, Vignudelli T, Ferrari S, Mor M, Scalvini L, Bolognesi ML, Uliassi E, Costi MP. The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment. J Med Chem. 2015 Jun 25;58(12):4857-73. doi: 10.1021/jm501615v. Epub 2015 Mar 11. Review. PubMed PMID: 25719868.
47: Neres J, Hartkoorn RC, Chiarelli LR, Gadupudi R, Pasca MR, Mori G, Venturelli A, Savina S, Makarov V, Kolly GS, Molteni E, Binda C, Dhar N, Ferrari S, Brodin P, Delorme V, Landry V, de Jesus Lopes Ribeiro AL, Farina D, Saxena P, Pojer F, Carta A, Luciani R, Porta A, Zanoni G, De Rossi E, Costi MP, Riccardi G, Cole ST. 2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1. ACS Chem Biol. 2015 Mar 20;10(3):705-14. doi: 10.1021/cb5007163. Epub 2014 Dec 9. PubMed PMID: 25427196.
48: Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP. Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J Med Chem. 2015 Jan 22;58(2):1012-8. doi: 10.1021/jm5011176. Epub 2014 Dec 29. PubMed PMID: 25427005.
49: Cannazza G, Cazzato AS, Marraccini C, Pavesi G, Pirondi S, Guerrini R, Pelà M, Frassineti C, Ferrari S, Marverti G, Ponterini G, Costi MP. Internalization and stability of a thymidylate synthase Peptide inhibitor in ovarian cancer cells. J Med Chem. 2014 Dec 26;57(24):10551-6. doi: 10.1021/jm501397h. Epub 2014 Dec 3. PubMed PMID: 25353379.
50: Genovese F, Gualandi A, Taddia L, Marverti G, Pirondi S, Marraccini C, Perco P, Pelà M, Guerrini R, Amoroso MR, Esposito F, Martello A, Ponterini G, D’Arca D, Costi MP. Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides. J Proteome Res. 2014 Nov 7;13(11):5250-61. doi: 10.1021/pr500510v. Epub 2014 Sep 29. Erratum in: J Proteome Res. 2016 Oct 7;15(10 ):3944. PubMed PMID: 25196676.
51: Tondi D, Venturelli A, Bonnet R, Pozzi C, Shoichet BK, Costi MP. Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative. J Med Chem. 2014 Jun 26;57(12):5449-58. doi: 10.1021/jm5006572. Epub 2014 Jun 16. PubMed PMID: 24882105; PubMed Central PMCID: PMC4079326.
52: Piras S, Carta A, Briguglio I, Corona P, Paglietti G, Luciani R, Costi MP, Ferrari S. 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem. 2014 Mar 21;75:169-83. doi: 10.1016/j.ejmech.2014.01.048. Epub 2014 Jan 30. PubMed PMID: 24531230.
53: Pelà M, Saxena P, Luciani R, Santucci M, Ferrari S, Marverti G, Marraccini C, Martello A, Pirondi S, Genovese F, Salvadori S, D’Arca D, Ponterini G, Costi MP, Guerrini R. Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth. J Med Chem. 2014 Feb 27;57(4):1355-67. doi: 10.1021/jm401574p. Epub 2014 Feb 12. PubMed PMID: 24450514.
54: Farina D, Spyrakis F, Venturelli A, Cross S, Tondi D, Costi MP. The inhibition of extended spectrum β-lactamases: hits and leads. Curr Med Chem. 2014;21(12):1405-34. Review. PubMed PMID: 24180276.
55: Ferrari S, Calò S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. 2’-Deoxyuridine 5’-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem. 2013 Nov 27;56(22):9356-60. doi: 10.1021/jm4014086. Epub 2013 Nov 13. PubMed PMID: 24147825.
56: Marverti G, Ligabue A, Lombardi P, Ferrari S, Monti MG, Frassineti C, Costi MP. Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells. Int J Oncol. 2013 Oct;43(4):1269-80. doi: 10.3892/ijo.2013.2045. Epub 2013 Jul 31. PubMed PMID: 23903781.
57: Garg D, Beribisky AV, Ponterini G, Ligabue A, Marverti G, Martello A, Costi MP, Sattler M, Wade RC. Translational repression of thymidylate synthase by targeting its mRNA. Nucleic Acids Res. 2013 Apr;41(7):4159-70. doi:10.1093/nar/gkt098. Epub 2013 Feb 18. PubMed PMID: 23423353; PubMed Central PMCID: PMC3627590.
58: Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035. Epub 2013 Jan 8. PubMed PMID: 23301156; PubMed Central PMCID: PMC3539145.
59: Ferrari S, Ingrami M, Soragni F, Wade RC, Costi MP. Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors. Bioorg Med Chem Lett. 2013 Feb 1;23(3):663-8. doi: 10.1016/j.bmcl.2012.11.117. Epub 2012 Dec 7. PubMed PMID:23273520.
60: Guerrieri D, Ferrari S, Costi MP, Michels PA. Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol. 2013 Mar;133(3):250-4. doi: 10.1016/j.exppara.2012.11.013. Epub 2012 Dec 1. PubMed PMID: 23206955.