61: Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP. Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J Med Chem. 2012 Nov 26;55(22):10272-6. doi: 10.1021/jm300850v. Epub 2012 Nov 5. PubMed PMID: 23075414.
62: Pozzi C, Ferrari S, Cortesi D, Luciani R, Stroud RM, Catalano A, Costi MP, Mangani S. The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1232-41. doi: 10.1107/S0907444912026236. Epub 2012 Aug 18.nPubMed PMID: 22948925.
63: Giudice S, Benassi L, Bertazzoni G, Veratti E, Morini D, Azzoni P, Costi MP, Venturelli A, Pirondi S, Seidenari S, Magnoni C. Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines. Invest New Drugs. 2012 Aug;30(4):1484-92. doi: 10.1007/s10637-011-9733-2. Epub 2011 Sep 1. PubMed PMID: 21881917.
64: Minozzi M, Lattanzi G, Benz R, Costi MP, Venturelli A, Carloni P. Permeation through the cell membrane of a boron-based β-lactamase inhibitor. PLoS One. 2011;6(8):e23187. doi: 10.1371/journal.pone.0023187. Epub 2011 Aug 17. PubMed PMID: 21858024; PubMed Central PMCID: PMC3157353.
65: Marverti G, Guaitoli G, Ligabue A, Frassineti C, Monti MG, Lombardi P, Costi MP. Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. Amino Acids. 2012 Feb;42(2-3):641-53. doi:10.1007/s00726-011-1039-3. Epub 2011 Aug 4. PubMed PMID: 21814787.
66: Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen OM, Ferrari S, Marverti G, Guerrieri D, Ligabue A, Frassineti C, Pozzi C, Mangani S, Fessas D, Guerrini R, Ponterini G, Wade RC, Costi MP. Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E542-9. doi: 10.1073/pnas.1104829108. Epub 2011 Jul 27. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16133. PubMed PMID: 21795601; PubMed Central PMCID: PMC3161595.
67: Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67. doi: 10.1021/jm2005018. Epub 2011 Jul 12. PubMed PMID: 21696158.
68: Ferrari S, Morandi F, Motiejunas D, Nerini E, Henrich S, Luciani R, Venturelli A, Lazzari S, Calò S, Gupta S, Hannaert V, Michels PA, Wade RC, Costi MP. Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. J Med Chem. 2011 Jan 13;54(1):211-21. doi: 10.1021/jm1010572. Epub 2010 Dec 2. PubMed PMID:21126022.
69: Carosati E, Sforna G, Pippi M, Marverti G, Ligabue A, Guerrieri D, Piras S, Guaitoli G, Luciani R, Costi MP, Cruciani G. Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors. Bioorg Med Chem. 2010 Nov 15;18(22):7773-85. doi:10.1016/j.bmc.2010.09.065. Epub 2010 Oct 1. PubMed PMID: 20951595.
70: Garg D, Henrich S, Salo-Ahen OM, Myllykallio H, Costi MP, Wade RC. Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J Med Chem. 2010 Sep 23;53(18):6539-49. doi:10.1021/jm901869w. Review. PubMed PMID: 20527892.
71: Tondi D, Calò S, Shoichet BK, Costi MP. Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3416-9. doi: 10.1016/j.bmcl.2010.04.007. Epub 2010 Apr 9. PubMed PMID: 20452208; PubMed Central PMCID: PMC3177945.
72: Costi MP, Zeillinger R. Drug resistance in ovarian cancer: biomarkers and treatments Highlights from the DROC meeting held in Modena (Italy) on the 19th and 20th of February 2009. Scientific topics discussed at the meeting are reported in the present issue. Gynecol Oncol. 2010 May;117(2):149-51. doi:10.1016/j.ygyno.2010.03.006. PubMed PMID: 20363442.
73: Genovese F, Ferrari S, Guaitoli G, Caselli M, Costi MP, Ponterini G. Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer. Protein Sci. 2010 May;19(5):1023-30. doi:10.1002/pro.379. PubMed PMID: 20306493; PubMed Central PMCID: PMC2868244.
74: Cardinale D, Salo-Ahen OM, Ferrari S, Ponterini G, Cruciani G, Carosati E, Tochowicz AM, Mangani S, Wade RC, Costi MP. Homodimeric enzymes as drug targets. Curr Med Chem. 2010;17(9):826-46. Review. PubMed PMID: 20156173.
75: Marverti G, Ligabue A, Guerrieri D, Paglietti G, Piras S, Costi MP, Farina D, Frassineti C, Monti MG, Moruzzi MS. Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines. Gynecol Oncol. 2010 May;117(2):202-10. doi:10.1016/j.ygyno.2009.11.030. Epub 2010 Jan 19. PubMed PMID: 20031193.
76: Cardinale D, Salo-Ahen OM, Guaitoli G, Ferrari S, Venturelli A, Franchini S, Battini R, Ponterini G, Wade RC, Costi MP. Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding. Protein Eng Des Sel. 2010 Feb;23(2):81-9. doi:10.1093/protein/gzp075. Epub 2009 Dec 2. PubMed PMID: 19955218.
77: Marverti G, Ligabue A, Paglietti G, Corona P, Piras S, Vitale G, Guerrieri D, Luciani R, Costi MP, Frassineti C, Moruzzi MS. Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells. Eur J Pharmacol. 2009 Aug 1;615(1-3):17-26. doi: 10.1016/j.ejphar.2009.04.062. Epub 2009 May 14. PubMed PMID: 19446547.
78: Costi MP, Ferrari S. Biochemistry: Anchors away. Nature. 2009 Apr 16;458(7240):840-1. doi: 10.1038/458840a. PubMed PMID: 19370021.