79: Calò S, Tondi D, Ferrari S, Venturelli A, Ghelli S, Costi MP. Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases. Chembiochem. 2008 Mar 25;9(5):779-90. doi: 10.1002/cbic.200700524. PubMed PMID: 18344216.
80: Babaoglu K, Simeonov A, Irwin JJ, Nelson ME, Feng B, Thomas CJ, Cancian L, Costi MP, Maltby DA, Jadhav A, Inglese J, Austin CP, Shoichet BK. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J Med Chem. 2008 Apr 24;51(8):2502-11. doi: 10.1021/jm701500e. Epub 2008 Mar 12. PubMed PMID: 18333608; PubMed Central PMCID: PMC2655312.
81: Costi MP, Taramelli D, González-Pacanowska D. Opening opportunities for new drugs against neglected diseases. ChemMedChem. 2008 Mar;3(3):371-3. doi: 10.1002/cmdc.200800036. PubMed PMID: 18324713.
82: Ferrari S, Losasso V, Costi MP. Sequence-based identification of specific drug target regions in the thymidylate synthase enzyme family. ChemMedChem. 2008 Mar;3(3):392-401. doi: 10.1002/cmdc.200700215. Review. PubMed PMID: 18270995.
83: Cavazzuti A, Paglietti G, Hunter WN, Gamarro F, Piras S, Loriga M, Allecca S, Corona P, McLuskey K, Tulloch L, Gibellini F, Ferrari S, Costi MP. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1448-53. doi: 10.1073/pnas.0704384105. Epub 2008 Feb 1. PubMed PMID: 18245389; PubMed Central PMCID: PMC2234164.
84: Venturelli A, Tondi D, Cancian L, Morandi F, Cannazza G, Segatore B, Prati F, Amicosante G, Shoichet BK, Costi MP. Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem. 2007 Nov 15;50(23):5644-54. Epub 2007 Oct 23. PubMed PMID: 17956081.
85: Corona P, Loriga M, Costi MP, Ferrari S, Paglietti G. Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities. Eur J Med Chem. 2008 Jan;43(1):189-203. Epub 2007 Apr 18. PubMed PMID: 17532099.
86: Giudice S, Benassi L, Bertazzoni G, Costi MP, Gelain A, Venturelli A, Bernardi C, Gualdi G, Coppi A, Rossi T, Giannetti A, Magnoni C. New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines. Toxicol In Vitro. 2007 Mar;21(2):240-8. Epub 2006 Oct 6. PubMed PMID: 17118621.
87: Benassi L, Magnoni C, Giudice S, Bertazzoni G, Costi MP, Rinaldi M, Venturelli A, Coppi A, Rossi T. Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents. Anticancer Res. 2006 Sep-Oct;26(5A):3499-504. PubMed PMID: 17094473.
88: Costi MP, Gelain A, Barlocco D, Ghelli S, Soragni F, Reniero F, Rossi T, Ruberto A, Guillou C, Cavazzuti A, Casolari C, Ferrari S. Antibacterial agent discovery using thymidylate synthase biolibrary screening. J Med Chem. 2006 Oct 5;49(20):5958-68. PubMed PMID: 17004711.
89: Pérez-Victoria JM, Cortés-Selva F, Parodi-Talice A, Bavchvarov BI, Pérez-Victoria FJ, Muñoz-Martínez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F. Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux. Antimicrob Agents Chemother. 2006 Sep;50(9):3102-10. PubMed PMID: 16940108; PubMed Central PMCID: PMC1563564.
90: Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005 Sep 28. PubMed PMID: 16204883.
91: Costi MP, Ferrari S, Venturelli A, Calò S, Tondi D, Barlocco D. Thymidylate synthase structure, function and implication in drug discovery. Curr Med Chem. 2005;12(19):2241-58. Review. PubMed PMID: 16178783.
92: Tondi D, Morandi F, Bonnet R, Costi MP, Shoichet BK. Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. J Am Chem Soc. 2005 Apr 6;127(13):4632-9. PubMed PMID: 15796528; PubMed Central PMCID: PMC1360654.
93: Tondi D, Venturelli A, Ferrari S, Ghelli S, Costi MP. Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine. J Med Chem. 2005 Feb 24;48(4):913-6. PubMed PMID: 15715461.
94: Buzzoni V, Blazquez J, Ferrari S, Calò S, Venturelli A, Costi MP. Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3979-83. PubMed PMID: 15225711.
95: Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug;16(8):607-14. PubMed PMID: 12968078.
96: Ghelli S, Rinaldi M, Barlocco D, Gelain A, Pecorari P, Tondi D, Rastelli G, Costi MP. ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity. Bioorg Med Chem. 2003 Mar 20;11(6):951-63. PubMed PMID: 12614880.
97: Loriga M, Piras S, Paglietti G, Costi MP, Venturelli A. Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities. Farmaco. 2003 Jan;58(1):51-61. PubMed PMID: 12595037.
98: Costi MP, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Soragni F, Venturelli A, Stroud RM. Structure-based studies on species-specific inhibition of thymidylate synthase. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):206-14. Review. PubMed PMID: 12084462.